FITC标记的载脂蛋白B抗体
产品名称： FITC标记的载脂蛋白B抗体
英文名称： Anti-ApoB /FITC
产品编号： HZ-6333R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围：
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-ApoB /FITC Conjugated antibody
FITC标记的载脂蛋白B抗体
| 英文名称 | Anti-ApoB /FITC |
| 中文名称 | FITC标记的载脂蛋白B抗体 |
| 别 名 | Apo B 100; Apo B; Apo B-100; Apo B-48; ApoB 100; ApoB 48; ApoB; APOB protein; APOB_HUMAN; Apolipoprotein B 100; Apolipoprotein B 48; Apolipoprotein B; Apolipoprotein B-48; FLDB. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, |
| 产品应用 | not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 241/513kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Apolipoprotein B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors. Function: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Subcellular Location: Secreted. Post-translational modifications: Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle. DISEASE: Defects in APOB are a cause of familialhypobetalipoproteinemia type 1 (FHBL1) [MIM:107730]. A disordercharacterized by highly reduced plasma concentrations of lowdensity lipoproteins, and dietary fat malabsorption. Clinicalpresentation may vary from no symptoms to severe gastrointestinaland neurological dysfunction similar to abetalipoproteinemia. Defects in APOB are a cause of familial ligand-defectiveapolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantlyinherited disorder of lipoprotein metabolism leading tohypercholesterolemia and increased proneness to coronary arterydisease (CAD). The plasma cholesterol levels are dramaticallyelevated due to impaired clearance of LDL particles by defectiveAPOB/E receptors. Note=Defects in APOB associated with defects in othergenes (polygenic) can contribute to hypocholesterolemia. Similarity: Contains 1 vitellogenin domain. Database links: Entrez Gene: 338 Human Entrez Gene: 238055 Mouse Omim: 107730 Human SwissProt: P04114 Human SwissProt: E9Q414 Mouse Unigene: 120759 Human Unigene: 221239 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Apolipoprotein B是乳糜微粒（APO B-48）、LDL（APO B-100）和VLDL（APO B-100）的主要蛋白组分。APO B-100作为APL O/E受体对LDL颗粒的细胞结合和内化的识别信号。
参与疾病：APOB的缺陷是家族性1型（FHBL1）低β蛋白血症的原因。一种疾病，其特征是血浆浓度低的低密度脂蛋白和膳食脂肪吸收不良。临床表现可能从没有症状到严重的胃肠道和神经功能障碍，类似于脂蛋白血症。APOB中的缺陷是家族性配体缺陷型载脂蛋白B-100（FDB）的一个原因。FDB是脂蛋白代谢的主要遗传性疾病，导致高胆固醇血症和冠状动脉疾病（CAD）倾向增加。血浆胆固醇水平显著升高，是由于缺陷的APOB/E受体对LDL颗粒的清除能力降低所致。