UBE3A (N-term) Peptide
产品名称： UBE3A (N-term) Peptide
英文名称： UBE3A (N-term) Peptide
产品编号： P0959
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of UBE3A.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human UBE3A.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Solution structure determination and mutational analysis of the papillomavirus E6 interacting peptide of E6AP.
Be X, Hong Y, Wei J, Androphy EJ, Chen JJ, Baleja JD.Biochemistry. 2001 Feb 6;40(5):1293-9.
- 2.
- The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.
Kleijnen MF, Shih AH, Zhou P, Kumar S, Soccio RE, Kedersha NL, Gill G, Howley PM.Mol Cell. 2000 Aug;6(2):409-19.
- 3.
- Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.
Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP.Science. 1999 Nov 12;286(5443):1321-6.
- Entrez GeneID:
- 7337
- Protein Accession#:
- Q05086
- Gene Name:
- UBE3A
- Gene Alias:
- ANCR,AS,E6-AP,EPVE6AP,FLJ26981,HPVE6A
- Gene Description:
- ubiquitin protein ligase E3A
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq
- Other Designations:
- CTCL tumor antigen se37-2,human papilloma virus E6-associated protein,oncogenic protein-associated protein E6-AP
- Gene Pathway