FITC标记的原钙粘蛋白11抗体
产品名称： FITC标记的原钙粘蛋白11抗体
英文名称： Anti-PCDHA11/FITC
产品编号： HZ-11124R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHA11/FITC Conjugated antibody
FITC标记的原钙粘蛋白11抗体
| 产品编号 | bs-11124R-FITC |
| 英文名称 | Anti-PCDHA11/FITC |
| 中文名称 | FITC标记的原钙粘蛋白11抗体 |
| 别 名 | PCDHA 11; PCDHA-11; Protocadherin alpha-11; Protocadherin alpha 11; PCDAB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 100kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHA11 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA11 is a 949 amino acid single-pass transmembrane protein that contains six cadherin domains and functions as a potential calcium-dependent cell-adhesion protein, possibly playing a role in the creation and maintenance of neuronal connections. There are two isoforms of PCDHA11 that are produced as a result of alternative splicing events. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56138 Human SwissProt: Q9Y5I1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
原粘蛋白是一大类钙黏蛋白样细胞粘附蛋白，参与脑内神经元连接的建立和维持。共有三个原粘蛋白（PCDH）基因簇，命名为α、β和γ，它们都含有多个排列整齐的基因。PCDHα基因的蛋白产物与整合素1相互作用，促进细胞黏附，并在特定的膜部位形成具有PCDHγ蛋白的寡聚体。PCDHA11是一个949氨基酸的单程跨膜蛋白，含有六个钙黏蛋白结构域，并起着潜在的钙依赖性细胞粘附蛋白的作用，可能在神经元连接的产生和维持中起作用。作为替代剪接事件的结果，产生了两种PCDHA11异构体。