Anti-BiP/GRP78(C-term) Monoclonal Antibody

品牌：solarbio | 货号：K001364M

商品货号：	商品品牌：	规格	基本售价：	选择规格
K001364M-50ul	solarbio	50ul	960.00元
K001364M-100ul	solarbio	100ul	1600.00元

英文名称 Anti-BiP/GRP78(C-term) Monoclonal Antibody
别名 BIP;GRP78;HEL-S-89n;MIF2
应用 WB ICC IHC
稀释比例 WB 1:1000. IHC 1:50.
交叉反应 Human Rat
蛋白分子量 78kDa
Gene ID 3309
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法 Affinity purification
亚型 IgG1
免疫原 Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli.
性状 液体
Public Immunogen Range Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli.
Subcellular Locations Cytoplasm Endoplasmic reticulum lumen Melanosome
Swiss Prot P11021
克隆号 9E4-2A7-H6
克隆类型 Monoclonal Antibody
背景资料 The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

英文名称	Anti-BiP/GRP78(C-term) Monoclonal Antibody
别名	BIP;GRP78;HEL-S-89n;MIF2
应用	WB ICC IHC
稀释比例	WB 1:1000. IHC 1:50.
交叉反应	Human Rat
蛋白分子量	78kDa
Gene ID	3309
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli.
性状	液体
Public Immunogen Range	Purified recombinant human BiP/GRP78 (C-terminus) protein fragments expressed in E.coli.
Subcellular Locations	Cytoplasm Endoplasmic reticulum lumen Melanosome
Swiss Prot	P11021
克隆号	9E4-2A7-H6
克隆类型	Monoclonal Antibody
背景资料	The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.